OTF7000 Cryostat
Our OTF7000 Cryostat is the latest version of our machines designed to deliver reproduceable tissue sections with precise temperature control. This cryostat can handle a large number of specimens and is available in two models, with the OTF7000/A benefitting from motorised sectioning.
A High Quality and Versatile Cryostat
This high quality and versatile cryostat is expertly engineered for a wide range of applications, including:
- Biological research
- Pathological diagnosis
- Pharmaceutical research
- Neuroanatomical research
- Clinical cryo-sectioning needs
The OTF7000 Cryostat is available as the OTF7000 (semi-automated) or the OTF7000/A (fully-automated). Read on to find out more.
Product Overview
Both machines include:
- UV – to handle varying biological specimen types with UVC for increased user safety
- Individually controlled temperature settings on both the cryochamber and the specimen holder
The OTF7000/A includes all the features of the OTF7000 model with the following additions:
- Motorised sectioning to improve reproducibility
There are also a wide range of useful accessories to create the ideal operational environment in your laboratory.
Contact us to find out more.
This high quality and versatile cryostat is expertly engineered for a wide range of applications, where sectioning precision and reproducibility is paramount – Such applications include:
Clinical Histology and Pathology: – for rapid diagnosis in clinic via intraoperative frozen section analysis, tumor profiling, detecting metastasis, or assessing treatment efficacy.
Immunohistochemistry: – Protein localization & study of cellular markers, antigens, and disease markers.
Developmental Biology: – The study of organogenesis & cellular differentiation, stem cell & tissue engineering, and molecular composition of tissues at different stages of development.
Pharmacology & Toxicology: – To document therapeutic outcomes, pharmacokinetics & bio-distribution & function.
Immunology & Infectious disease: Distribution of pathogens & immune cells, inflammation & response to infection, autoimmune disease research.
Spatial Transcriptomics: This cutting edge technology allows the mapping of gene expressions within tissue architecture at high spatial resolution. Proper sectioning is the foundation for successful data acquisition—meticulous preparation will maximize your results!
Neurology, cardiology, oncology & other non-infectious disease: Cryosectioning clinical tissue allows study of disease progression, pathological features of diseases, cellular changes, gene expression & mechanism of disease.
High Precision Temperature Control
Our cryostat is extremely consistent, both in terms of temperature control and sectioning quality.
Temperatures are regulated in the cryochamber between 0 to – 35°C.
- An intelligent temperature control system
- Variable speed compressor
- Sample cooling system that includes an adjustable temperature range of between -10°C and-50°C, via a cooled Peltier system offering faster temperature
- A ‘Cryobar’ sample preparation station which rapidly cools to -60°C
Stable Section Quality
Stable sectioning is maintained by:
- Precision cross roller guide rails that guarantee section smoothness and accuracy
- Precise screw rods that meet 0.5µm sample injection requirements
- Five phase, high resolution stepping motor with higher positioning accuracy and lower motor vibration
- Horizontal sampling slide crafted from ultra-high strength and corrosion resistant aviation grade aluminium
Integrated Safety Features
The OTF7000 cryostat includes a range of important safety features:
- High-tech, low-temperature UVC disinfection technology that kills bacteria and viruses at an intensity of above 340 uw/ cm ², within both the inner surface and the air inside the cabinet.
- Ergonomic exterior cabinet with a circular arc design. This is available with an optional height-adjustable foot rest for seated operation.
- Section waste is easily removed using the optional section waste removal system so that no manual cleaning is required.
- Integrated waste management system that displays waste liquid volume on the touch screen.
- An alarm to notify the user when the waste management bottle is full.
Efficient and Energy Saving
This expertly engineered machine delivers efficiency with:
- A visually appealing 7 inch touch-sensitive screen.
- A joystick that controls coarse sampling, trimming and section switching, as well as section parameter adjustment.
- Rapid and precise positioning with ±8° visual pointer facilitating adjustment of the specimen clamp to the target angle. This reduces trimming and sample waste.
- Efficient defrosting with a variety of options.
- Auto-sectioning option available for ease of use and consistent sectioning of all specimen types.
- Automatic sleep and wake-up feature that saves energy.
- Specimen loading via a single lever operation.
- Specimen marking to easily record and identify each sample.
Please contact your specialist here to find out more to discuss bespoke solutions.
Full Details
Specification 
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Both OTF7000 and OTF7000/A Cryostats Include:
Section thickness setting range: 0.50–100 µm -
Trimming section thickness setting range: 1–800 µm -
Electric sectioning speed: 0-1800µm adjustable -
Specimen retraction: 0-250μm adjustable -
Specimen feed: 28mm -
Vertical stroke: 70mm -
Working Height 1025mm -
Specimen horizontal & vertical rotation: X/ Y axis 8° -
Number of refrigerated sites: 15 -
Number of fast cooling sites: 2 -
Cabinet refrigeration temperature: 0℃to -35℃ -
Sample head minimum cooling temperature: - 50℃ -
Accepts high and low profile microtome blades -
230v~ 50Hz 1350VA -
Weight ~ 183kg -
Width/depth/height 853mm ×863mm ×1210mm -
OTF7000/A:
Fully automated and semi-automated mode switch -
Emergency stop button -
Cut window function -
Electric sectioning speed 0.5-450 mm/s -
Multiple sectioning modes -
Optional foot pedalfor motor control -
230v~ 50Hz 1450VA -
Weight ~185kg
Accessories & Replacement Blades
Accessories
The following accessories are also available:
- FS800-F3: Stationary heat extractor
- 255-820: Adjustable foot rest
- S700A- F3: Foot switch (OTF7000 (A)
- FS800-F2: Blade holder assembly
- FS800-F14: Movable shelf
- FS800-F21: Storage system
- FS800: Specimen discs:
- FS800-F4 Specimen disc φ20
- FS800-F5 Specimen disc φ30
- FS800-F6 Specimen disc φ40
- FS800-F7 Specimen disc φ55
Replacement Microtome Blades (50241)
- Low profile microtome blade featuring PLASMA technology
- Dimensions: 0.010″ x 3.15″ / 254mm x 80mm
- 35° angle
- 50 pcs
Downloads
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Brochure
Product Video
Coming Soon…
Case Studies And Downloads
Queen Mary, University of London Case Study
The William Harvey Research Institute, part of Queen Mary, University of London, is conducting pioneering work at its Centre for Experimental Medicine and rheumatology (EMR). EMR is the leading centre globally for biopsy-driven, stratified-medicine randomised clinical trials for rheumatoid arthritis. An existing Bright Instruments client, the EMR needed to upgrade its existing cryostat to boost operational efficiency. We were delighted to demonstrate the benefits that our latest OTF7000 Cryostat had to offer.
OTF7000 Brochure
Our OTF7000 Cryostat is the latest version of our machines designed to deliver reproduceable tissue sections with precise temperature control. This cryostat can handle a large number of specimens and is available in two models, with the OTF7000/A benefitting from motorised sectioning. This high quality and versatile cryostat is expertly engineered for a wide range of applications, including
OTF7000 Energy Consumption Report
Cryostats are used in surgical diagnosc procedures and disease research to cut histological ssue secons.The set temperature employed by the cryostat will vary depending upon the ssue being cut. Typically, the cryostat chamber temperature will be set from -20○C to -30○C.
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